ABSTRACT

Diabetes is considered as one of the most common metabolic disorder. It has challenged in terms of diagnosis, monitoring and management in the patients with type-2 diabetes. Glycosylated Hemoglobin (HbA1c) has recently been validated for the diagnosis diabetes in non-fasting condition, long term blood glycose monitoring and also predicting its complications in the patients. National Glycohemoglobin Standardization Program and International Federation of Clinical chemistry have been collaborating for the harmonization of HbA1c methods and directing the laboratories to maintain strict quality goals. However, standardization of various HbA1c methods being used worldwide still needs consideration especially in diabetic patients having hemoglobin variants.  The main objectives are to review HbA1c methods and address challenges in its measurement methodology for the patients with diabetes mellitus having hemoglobin variants or chemically modified derivatives. Thus, to provide guidance to the clinical pathologist for selection of appropriate method for their laboratories.

Key Words: Capillary Electrophoresis, Diabetes, Glycated Hemoglobin HbA1C, Hemoglobin Variants, HPLC.

How to cite this: Khan DA, Nida S. Challenges in Hemoglobin A1C Measurement in Patients with Diabetes having Hemoglobin Variants and Chemically Modified Derivatives. Life and Science. 2021; 2(4): 182-188.  doi: http://doi.org/10.37185/LnS.1.1.98